Below is a link to the Review Article which showcases a new paradigm to preventing cancer recurrence using natural therapies. You can download the free PDF from the SAGE site.
The title is: A Review of Natural Therapies Potentially Relevant in Triple Negative Breast Cancer Aimed at Targeting Cancer Cell Vulnerabilities. Published in Integrative Cancer Therapies, Vol 17 2020 Webb & Kukard.
10 Biochemical pathways
that cancer cells use to grow
- HIF-1hypoxic factor
- Hedgehog canonical signaling pathway
- MAPK pathway
- MTAP used for polyamine synthesis
- NF-ÎșB signaling pathway
- Notch pathway (Ligands: Jagged1, Jagged2, and
ÎŽ-like ligand 1, 3, and 4) - PI3K/Akt/mTOR signaling pathway
- p53 and POLR2A gene expression
- STAT3 signaling pathway
- Wnt/ ÎČ-catenin pathway
HIF-1hypoxic factor
Parts of hypoxic tumors have lower oxygen
concentrations than healthy tissue.
This hypoxic tumor environment selects more for a malignancy with increased mutation rates, evasion of apoptosis (programmed cell
death), cell proliferation and less drug permeability.
HIF-1 has a dominant role in the response to acute hypoxia and HIF-2 in chronic hypoxia in solid cancer tumors.
HIF-1 regulates transcription of genes encoding glycolytic pathway enzymes, for example, Lactate dehydrogenase exhibits oxygen dependent regulation.
Hedgehog canonical signaling pathway
The Hedgehog/ glioma-associated oncogene pathway is a signaling cascade fundamental for functions in vertebrate embryogenesis and adult tissue homeostasis.
During evolution the Hedgehog pathway has diverged and intermeshed with other signaling pathways to control cell growth and patterning.
For information about my book STAGES OF SUICIDE-HOW TO HELP YOUR MIND,
This takes you to my other website.